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KMID : 0613820080180060891
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Journal of Life Science
2008 Volume.18 No. 6 p.891 ~ p.896
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The Role of Mast Cells in Innate and Adaptive Immunity
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Kim Young-Hee
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Abstract
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The function of mast cells as effector cells in allergy has been extensively studied. Mast cells activated through high affinity IgE-receptor (FcεRI) release diverse mediators, and lead to smooth muscle constriction, vasodilation, increase of vascular permeability, leukocyte recruitment and activation, mucus secretion, and tissue proliferation and remodeling. However, various other immunological and non-immunological signals can lead to the activation of mast cells. In resent years, mast cells have been identified to be involved in a complex range of immune functions. Mast cells can be important as key players in the regulation of innate as well as adapted immune responses, and may influence the development of allergy, autoimmune disorder and peripheral tolerance. This review summarizes the recent advances in the understanding of effector functions of mast cells in immune responses.
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KEYWORD
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Mastcell, innateimmunity, adaptiveimmunity, allergy, chronicinflammation
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